Trifluoroacetyl chloride, a gas at ambient conditions and sold as a liquid under pressure, provides a convenient way to introduce a trifluoromethyl group into complex organic molecules. It is used in the production of agricultural and pharmaceutical molecules.
When reacted with a compound containing active hydrogen it will yield a trifluoromethyl compound and hydrochloric acid as byproduct. Due to the electron withdrawing effect of CF3 group, the reactivity of the carbonyl group towards nucleophilic reagents is increased when compared to the non-fluorinated analogue.
Specifications:
Assay by Gas Chromatography
99.5% minimum
Hydrolyzable Fluoride
0.01% maximum
Physical Properties:
Mol. Wt.:
132.45
Boiling Pt:
-28°C
Melting Pt:
-146°C
Density:
1.384
Vapor Pressure:
72 psia (25°C)
Appearance and Odor:
Colorless liquefied gas with pungent odor.
Solubility in water:
Exothermic reaction with water to form water soluble trifluoroacetic acid and byproduct HCl.
